Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics

We now understand that cancer is a disease rooted in genomic breakdown. But when analyzing a patient’s genome, not all mutations contribute equally to disease. Further complicating things is the fact that, even after a gene’s role in cancer development is clearly established, only certain alterations can be targeted by current therapies. Therapeutically targetable mutations, therefore, are needles in the haystack for cancer researchers – which explains the recent excitement around the NTRK gene family...

Dr. Ryosuke Okamura January 22nd, 2020

user-image

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

The interplay between hereditary and somatic mutations in cancer development has been a difficult relationship for oncologists to unravel. While we now know that some cancers are indeed heritable, we don’t always know to what degree. Pediatric acute lymphoblastic leukemia (ALL) is one such disease, with a well-documented but still ambiguous hereditary component. A new study out of St. Jude’s Research Hospital – Somatic and germline genomics in paediatric acute lymphoblastic leukaemia (ALL) - expanded on the complex genetics of the disease. ..

Dr. Ching-Hon Pui December 17th, 2019

user-image

The Expanding Network of NTRK Fusions in CIFS: Beyond NTRK3-ETV6

Infantile fibroblastic and myofibroblastic tumors are the second most prevalent type of soft tissue neoplasms in pediatric patients < 1 years old. Although the majority of these tumors are either benign or low-grade, there are certain subtypes with a higher tendency toward malignancy. Congenital infantile fibrosarcoma (CIFS) is one such high-risk group. CIFS patients, who are nearly always less 2 years old, present with morphologically ambiguous tumors that can resemble a range of other infantile neoplasms of varying clinical course, including myofibroma/myofibromatosis, lipofibromatosis and fibrous hamartoma of infancy, primitive myxoid mesenchymal tumor of infancy (PMMTI), and dermatofibrosarcoma protuberans (DFSP)...

Dr. Jessica Davis December 05th, 2019

user-image

Alterations in ALK / ROS1 / NTRK / MET Drive a Group of Infantile Hemispheric Gliomas

Gliomas are rare brain tumors that can affect individuals of all ages. While studies are plentiful on pediatric and adult gliomas, infant cases are historically understudied – an unfortunate fact, considering central nervous system tumors are most common (and deadly) in this age group. This research team sought to account for that lack of data by cytogenetically analyzing infant glioma samples collected between 1986 and 2017. The team was able to divide these tumors into three genetic subtypes that were tightly tied to clinical outcome. Additionally, they found that many of the tumors harbored just a single genetic aberration, evidence that infant gliomas are usually single driver tumors...

Dr. Cynthia Hawkins December 03rd, 2019

user-image

Easy Living

category-image

Adventure

category-image

Storytime

category-image

Open Roads

category-image

Gaming

category-image

City Life

category-image

Rave Culture

category-image

Photography

category-image

Animal Kingdom

category-image

Beach

category-image

Climbing

category-image

Mystery

category-image
Empire Genomics Copyright 2020